Freeman Lab

News Archive

Graduate Students Receive Fellowships

Congratulations to Victor Ansere for being awarded an OMRF Pre-doctoral Scholarship endowed by the John and Mildred Carson PhD Scholarship Fund and Kyla Tooley for receiving a fellowship from the Oklahoma GeroScience Training Program though an NIH t32 award at OUHSC.

Sarah Ocanas elected American Aging Association Trainee Vice Chair/Secretary

Sarah Ocanas will be representing the OKC Geroscience community nationally through her election as Vice Chair/Secretary of the Trainee Chapter.  This chapter represents all trainees in the society from across the US.

GREAT Week Awards to Graduate Students

At the 2021 OUHSC Graduate Research Education And Technology (GREAT) Symposium students in the Freeman Lab won a number of awards:
  • Hunter Porter - GREAT Debate Winner
  • Sarah Ocanas - Paper of the Year Award and Dean's Award for Outstanding Research
  • Kyla Tooley - Vice President's for Research Award for Outstanding Research.
Congratulation to Hunter, Sarah, and Kyla for their achievements and to all the trainees in the Geroscience program who won nearly half of all the awards.

Graduate Student Hunter Porter Receives NIH Predoctoral Fellowship

Hunter Porter, neuroscience graduate student, has received an NIH Fellowship entitled "Mathematical Models of Vulnerability and Cell-Type Specific Analysis of DNA Modifications in Aging" to support his research and training.  Hunter's work applies advanced bioinformatic approaches to DNA methylation patterns to understand aging, disease, cellular senescence, and genomic regulation.  Hunter continues a trend of students receiving individual NIH predoctoral fellowships with 1/2 of the F31 awardees in Oklahoma over the past three years being in the Freeman Lab.

New grants to study epigenomics of aging

Two new collaborative projects have been funded to expand our epigenomics of aging studies.  With the laboratory of Dr. Michael Stout at the College of Allied Health at the University of Oklahoma Health Sciences Center a five year project 'Cellular senescence and epigenomic remodeling in ovarian aging" (R01AG069742) will examine theca, granulosa, and oocytes cells across the reproductive lifespan and the impact of senolytic treatments.  With the laboratory of Dr. Ben Miller in the Aging & Metabolism Program at the Oklahoma Medical Research Foundation a new one year High Priority, Short-Term Project Award 'A novel approach to understand a mechanisms of proteostatic decline with aging' is combining our NuTRAP mouse approaches with stable isotope labeling to understand protein turnover in specific cell types in the brain and muscle. As well, the Oklahoma Nathan Shock Center (P30AG050911) has been renewed for five years and will allow us to continue to provide services to the geroscience research community.

Graduate Student Victor Ansere Receives AFAR Fellowship

Congratulations to Victor Ansere for receiving a Diana Jacobs Kalman/AFAR Scholarship for Research in the Biology of Aging from the American Foundation for Aging Research.  This award will support Victor's research into the effects of heterochronic plasma transfer on brain aging and microglial activation.

Drs. Chucair-Elliott and Freeman receive BrightFocus Vision Grant

A project initiated by Dr. Ana Chucair-Elliott on age-related changes in the retinal epigenome has been funded by the BrightFocus Foundation.  The project "Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and Müller glia in age-related macular degeneration" will be examining glial age-related epigenomic alterations in the context of Age-related macular degeneration (AMD). The two year grant award will utilize new mouse models developed in the lab.

Ashley Martin Dissertation Defense

Congratulations to Ashley Martin for artfully completing and defending her Physiology PhD dissertation "MATERNAL ADIPOSITY ALTERS TRANSCRIPTOIMC AND EPIGENOMIC NEURODEVELOPMENTAL LANDSCAPES IN THE FETAL HIPPOCAMPUS."  Ashley has been an F31 awardee from the National Institute of Child Health and Human Development and will now be headed to a postdoctoral fellowship in medical and health professions education.

Graduate Student Sarah Ocanas Receives NIH Award

Freeman Lab graduate student Sarah Ocanas has received an NIH National Research Service Award for her project "EPIGENETIC REGULATION OF SEXUALLY DIVERGENT NEUROINFLAMMATION WITH BRAIN AGING AND ALZHEIMER'S DISEASE."  This will support Sarah and her work for the next three years.  Sarah joins Ashley Martin in the group as the only F31 awardees in the state of Oklahoma.

Hunter Porter Wins Harold Hamm Diabetes Center Presentation Award

Graduate Student Hunter Porter received a presentation award for his work on non-CpG methylation in metabolic memory and diabetic retinopathy.

NIH Grant Award to Support Brain Aging Research

The Freeman Lab received a new NIH grant award R01AG059430 “Sex divergence and cell specificity of age-related hippocampal DNA modifications” to support studies of glial and neuronal cell population with brain aging through 2024.

Sarah Ocanas wins PHF Graduate Fellowship

Congratulation to Sarah Ocanas for winning a Presbyterian Health Foundation fellowship for her work “Epigenetic regulation of sexually divergent neuroinflammation with brain aging”:

Students win awards at GREAT Week

Sarah Ocanas, Physiology Graduate Student, won the GREAT week Graduate Student Association Research Award

Hunter Porter, Neuroscience Graduate Student, won the GREAT week OK Bioscience Travel Award and the Graduate Student Flash Talk Award

Hunter Porter wins MCBIOS Award

At the 2019 MCBIOS Meeting Hunter Porter, Neuroscience Graduate Student, won the Best Student Oral Presentation Award.

OUHSC Receives Center of Biomedical Research Excellence (CoBRE) Award

Geroscience researchers has received an NIGMS CoBRE award to advance aging research in Oklahoma. This four year >$8 million dollar award will provide research cores, junior investigator awards, and pilot grants to continue the growth of the aging research program. The Freeman Lab will lead the Molecular Analysis and Cellular Imaging Core.

Hunter Porter Awarded NIH Fellowship

Hunter Porter, Neuroscience Graduate Student will be supported by an NIH Pre-doctoral fellowship through the Geroscience Program (T32AG052363 Geroscience Training Program in Oklahoma).

New Grant Awards to Support Neuroepigenomic Research

Two new research grants will support work in the laboratory. An NIH High Priority, Short-Term Project Award from the NIH (R56AG059430 Sex Divergence and Cell Specificity of Age-related Hippocampal DNA Modifications) will support continued development of NuTRAP transgenic mice. A VA MERIT Award (I01BX003906 Dynamics of the Brain Epigenome with Aging) will support our studies of prevention of age-related epigenetic modifications by caloric restriction.

Graduate Student Wins Best Dissertation Award

Dustin Masser Phd, former Physiology graduate student received the 2018 OUHSC Outstanding Dissertation Award.  This is given to one graduate student each year and recognizes a body of work from a gradate student's research.

Hunter Porter Wins MCBIOS2018 Poster Award

Hunter Porter, Neuroscience graduate student, won the Best Poster Award at the Midsouth Computational Biology & Bioinformatics Society meeting held at Mississippi State University for his poster Testing the Limits of the Epigenetic Clock

Graduate Students Present at Keystone DNA and RNA Methylation Meeting in Vancouver

January 2018 - Neuroscience graduate students Niran Hadad and Hunter Porter presented there work at the Keystone DNA and RNA Methylation meeting in Vancouver BC this month.  Niran presented his poster Differential Regulation of CG and non-CG Methylation by Caloric-Restriction in the Old Brain while Hunter's poster was Testing the Limits of the Epigenetic Clock

Freeman Lab Receives Two Oklahoma Center for Adult Stem Cell Research Grants

The Oklahoma Center for Adult Stem Cell Research has awarded to grants for stem cell research in the Freeman Lab.  The first project "Neuroepigenomics of Neural Stem Cell Aging" will continue development of genetic models for analysis of neural stem cells with aging.  The second grant will fund the purchase of a BioRad ddSeq instrument for single cell RNA sequencing studies. Thank you OCASCR!